This is a bug report actually. It seems that application-specific config for the MX Master 3S mouse doesn't properly work in Edge if clicking a link in Excel.

Procedure:
1. Ensure you have a custom Microsoft Edge configuration for your MX Master 3S
2. Open a spreadsheet with a hyperlink in it
3. Click the link
4. Attempt to use the custom action in Edge

Expected outcome:
1. Custom action in Edge (e.g. switching tabs with horizontal scroll wheel) works as expected

Actual outcome:
1. Custom action in Edge does not work; requires switching apps away from and back to Edge