The thumbwheel does not work smoothly with Pro tools - it skips large sections of the timeline instead. This is a widely known issue among Logitech/Pro Tools users. Many use a 3rd party software to fix this, but it is windows only. This is not an issue for Ableton, Reaper, etc -Just pro tools - the industry standard! Please Please Please fix this - I use it for work everyday and may have to switch to a Kensington at this point! Otherwise, I love the mouse and Options. Was hoping it could be fixed in this beta but looks like the horizontal scroll is still buggy.