The ability to assign key commands to the F-keys.

For example, I can start up a Snagit screenshot with the key command "Control-Shift-s" But if I assign the application Snagit to a key, I open the Snagit application, not a screenshot grab.

Being able to assign keyboard chords would be very valuable. Perhaps even to assign them from/for applications. For example, assigning an F-key to a specific Photoshop tool.