The horizontal scroll as implemented for the MX Master 3 (not for business) breaks the scrolling in MS Excel.
The horizontal scrolling works when you use it, but once you are done, the vertical scrolling doesn't work graphically. The scrolling moves the interactive area of the sheet, and clicking to select a cell actually changes the active cell selection, so if I had scrolled down half a screens worth and select the top cell, the cell halfway down the sheet gets selected.
The only way to fix this situation is to click and drag one of the scroll bars.