On macos 12.1, Intel16" MBP. On fresh startup, Options+ opens up without issues and all device/app customisations work. However, after some time (not sure on how long), when I realise that some MX Master 3 scroll button not working, and I try to open up Options+ it won't even open completely (i.e. stuck on the circling graphic and not proceeding to open to display the devices (MX Master 3 and MX Master Keys). At this point, Option+ will in never open anymore. e.g. Force Quitting and opening will not do anything either. The only solution is to reboot the machine and hope again that the failure will not happen too soon