If I have a profile for a game and open my webbrowser at the same time (on second monitor watching a video for example) the game profiles altered mouse buttons work in the browser too for some godforsaken reason.

I customize my forward/back side buttons in games but I really like having the work normally in my browser.

If I alt-tab to a different program, or the game is not the active window - its profile/ customizations should not be active and should behave according to the GLOBAL configuration.