When I swap the left and right buttons in the settings, then do a Remote Desktop connection to my work computer, it does not retain those settings like it does for my M557 mouse. In the original left handed mouse, when it was plugged in, the buttons were reversed by befault. All one had to do was connect it to a computer to have a fully function, buttons-reversed, left handed mouse. I was so excited that you finally came out with a new left handed mouse I bought three of them. When this issue came up the Remote Desktop connection, I almost sent all 3 of them back. I work from home but my PC is in the office. I changed my mind about sending them back (I REALLY WANT A LEFT HANDED MOUSE!) because I will be getting a laptop for work in the next few months, which I will use at home. I was SO EXCITED that you made a left handed mouse again, but missed the boat a bit. - Johnny Jones, a long time Logitech user. (I am using the logi keyboard as I type this.)