I previously provided feedback on an issue I've had across this beta and previous versions of the normal release software. I provided a lot of detail in that bug report, but to summarize: my mouse loses its customized button functions frequently when my Mac wakes up. Putting it back to sleep and waking it up fixes the issue (or so I thought).

UPDATES:
At least with the current version of the software, I've discovered a way to reliably reproduce the bug. This allowed me to do some digging and figure a few things out, which I've summarized in the attached screenshot. To reproduce the bug, I put my laptop to sleep, then shortly afterward wake it back up BY MOVING THE MOUSE (other methods don't cause the issue, or at least not as reliably). This is what I had done immediately prior to taking the screen recording.

In the recording, I demonstrate that the LogiOptions+ task is stuck in some sort of loop that consumes a ton of CPU, prevents the mouse from using the scroll wheels and most buttons. It also seems to prevent the software from launching. When I kill the process, the software immediately loads and my mouse regains its functionality, which you can see me testing. After I ended the process and stopped the recording, the CPU usage never spiked back up and my highest CPU temp dropped by over 30C.

Hope this helps you solve this issue as it clearly goes beyond what I thought was an annoying little bug! Feel free to contact me via email if you need more info.