I am using Logi Options+ on a 16" i9 MacBook Pro running macOS 12.0.1, and using Airplay to Mac, using a 13" M1 MacBook Air as a secondary display. I have an MX Master 3 for Mac mouse, and have been experiencing issues with the configured buttons randomly not operated as configured. If I power cycle the mouse, the buttons operate as configured, but will soon revert back to default settings. I have not yet tested if this happens without using AirPlay to Mac. I will attempt to do that and provide future feedback.