Windows navigation / switch desktops to left or right doesn't work with gestures (MacOS 11.5.2). However, it does any other action depending on the active application. E.g. when Safari is active and Windows navigation configured for gesture button, it calls Back and Forward page. In IntelliJ IDEA it changes editor tabs.

Workaround for not working Windows navigation was to assign keyboard shortcuts to gestures (which works reliably).